Dr Cutting holds positions at Aetna/U.S. Healthcare Professor of Pediatrics and Medicine, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland USA. Dr. Cutting's research is focused on the causes of phenotype variation in the single gene disorder cystic fibrosis (CF). He directs a worldwide project called CFTR2 that aims to characterize the clinical and functional consequences of all mutations reported in the CF transmembrane conductance regulator (CFTR), the gene that causes CF. Dr Cutting's laboratory also investigates the role of CFTR mutations in phenotypes that overlap with CF (chronic rhinosinusitis, male infertility and obstructive lung diseases). His current work involves the quantification of genetic and non-genetic factors to trait variation in CF and the elucidation of interactions among these factors. Genome-wide linkage and association methods are being used by his group to identify specific genetic modifiers of CF. Dr. Cutting's research is supported by the National of Heart, Lung and Blood Institute, the National Institute of Diabetes, Digestive and Kidney Disease, the U.S. CF Foundation and the Flight Attendants Medical Research Institute. Dr. Cutting has a MERIT award from the National Institutes of Health.
In addition to basic science activities, Dr. Cutting directs the DNA Diagnostic Laboratory at Johns Hopkins and the Translational Technology Core of the Institute for Clinical Translational Research at Hopkins. These translational science laboratories facilitate the development and implementation of clinical genetic tests derived from research discoveries of Hopkins investigators. Dr Cutting also directs the Post-doctoral Training Program in the Institute of Genetic Medicine that oversees Residency programs in Medical Genetics, Pediatrics and Genetics, Internal Medicine and Genetics, Maternal Fetal Medicine and Genetics and Clinical Laboratory programs in Biochemical, Cytogenetics and Molecular Diagnostics.
Dr. Cutting is certified in Clinical Genetics, Biochemical and Molecular Genetics by the American Board of Medical Genetics. He is a member of the American Society of Clinical Investigation and the Society for Pediatric Research. Dr. Cutting is the American Society of Human Genetics representative to the Federation of American Societies for Experimental Biology. He recently assumed the position of Co-Editor of the genetics journal Human Mutation.